A fannin maganin zamani, maganin rigakafi ya tabbatar da cewa yana ɗaya daga cikin manyan ci gaba, wanda hakan ya rage yawan mace-mace da ke tattare da kamuwa da cututtukan ƙwayoyin cuta. Ikonsu na canza sakamakon asibiti na kamuwa da ƙwayoyin cuta ya tsawaita tsawon rayuwar marasa lafiya marasa adadi. Maganin rigakafi yana da matuƙar muhimmanci a cikin hanyoyin likitanci masu rikitarwa, ciki har da tiyata, sanya dashen jiki, dashen jiki, da kuma maganin chemotherapy. Duk da haka, fitowar ƙwayoyin cuta masu jure wa maganin rigakafi ya zama abin damuwa, yana rage ingancin waɗannan magunguna akan lokaci. An rubuta misalan juriyar maganin rigakafi a cikin dukkan nau'ikan maganin rigakafi yayin da maye gurbi na ƙwayoyin cuta ke faruwa. Matsin lamba na zaɓi da magungunan ƙwayoyin cuta ke yi ya taimaka wajen ƙaruwar nau'ikan da ke jure wa magani, wanda hakan ya haifar da babban ƙalubale ga lafiyar duniya.
Domin magance matsalar da ke damun masu fama da cutar antimicrobial, yana da mahimmanci a aiwatar da ingantattun manufofin kula da kamuwa da cuta waɗanda ke rage yaɗuwar ƙwayoyin cuta masu juriya, tare da rage amfani da maganin rigakafi. Bugu da ƙari, akwai buƙatar ƙarin hanyoyin magani. Hyperbaric Oxygen Therapy (HBOT) ya fito a matsayin wata hanya mai kyau a cikin wannan mahallin, wanda ya haɗa da shaƙar iskar oxygen 100% a takamaiman matakan matsin lamba na ɗan lokaci. An sanya shi a matsayin magani na farko ko na ƙarin magani ga cututtuka, HBOT na iya ba da sabon bege wajen magance cututtukan da ke da saurin kamuwa da cuta waɗanda ƙwayoyin cuta masu juriya ga maganin rigakafi ke haifarwa.
Ana ƙara amfani da wannan maganin a matsayin magani na farko ko madadin ga cututtuka daban-daban, ciki har da kumburi, gubar carbon monoxide, raunuka na yau da kullun, cututtukan ischemic, da cututtuka. Amfanin HBOT a asibiti a cikin maganin kamuwa da cuta yana da matuƙar girma, yana ba da fa'idodi masu mahimmanci ga marasa lafiya.
Aikace-aikacen Asibiti na Hyperbaric Oxygen Therapy a cikin Kamuwa da cuta
Shaidun da ake da su a yanzu sun tabbatar da amfani da HBOT sosai, duka a matsayin magani mai zaman kansa da kuma na kari, wanda ke ba da fa'idodi masu yawa ga marasa lafiya da suka kamu da cutar. A lokacin HBOT, matsin lamba na iskar oxygen a cikin jini na iya tashi zuwa 2000 mmHg, kuma sakamakon haka, matsin lamba mai yawa na oxygen-tifs zai iya ɗaga matakan oxygen na nama zuwa 500 mmHg. Irin waɗannan tasirin suna da matuƙar muhimmanci wajen haɓaka warkar da martanin kumburi da katsewar ƙwayoyin cuta da aka gani a cikin yanayin ischemic, da kuma kula da ciwon sashin jiki.
HBOT kuma yana iya shafar yanayin da ya dogara da tsarin garkuwar jiki. Bincike ya nuna cewa HBOT na iya danne cututtukan autoimmune da martanin garkuwar jiki da antigen ke haifarwa, yana taimakawa wajen kiyaye juriyar dashen ƙwayoyin cuta ta hanyar rage zagayawar lymphocytes da leukocytes yayin da yake daidaita martanin garkuwar jiki. Bugu da ƙari, HBOTyana tallafawa warkarwaa cikin raunukan fata na yau da kullun ta hanyar ƙarfafa angiogenesis, muhimmin tsari don inganta murmurewa. Wannan maganin yana kuma ƙarfafa samuwar matrix na collagen, wani muhimmin mataki a cikin warkar da rauni.
Dole ne a ba da kulawa ta musamman ga wasu cututtuka, musamman cututtuka masu zurfi da wahalar magani kamar su necrotizing fasciitis, osteomyelitis, cututtukan nama mai laushi na yau da kullun, da kuma endocarditis mai kamuwa da cuta. Ɗaya daga cikin aikace-aikacen asibiti na HBOT shine don kamuwa da nama mai laushi na fata da osteomyelitis da ke da alaƙa da ƙarancin iskar oxygen wanda galibi ƙwayoyin cuta masu hana iskar oxygen ke haifarwa.
1. Cututtukan ƙafa na masu ciwon suga
ƙafar masu ciwon sukariCiwon mara matsala ce da ta zama ruwan dare a tsakanin masu ciwon suga, tana shafar har zuwa kashi 25% na wannan al'umma. Sau da yawa kamuwa da cuta kan taso a cikin waɗannan raunukan (wanda ya kai kashi 40%-80% na lokuta) kuma yana haifar da ƙaruwar rashin lafiya da mace-mace. Cututtukan ƙafafu masu ciwon suga (DFIs) galibi suna ƙunshe da cututtukan ƙwayoyin cuta masu yawa tare da nau'ikan ƙwayoyin cuta masu cutar anaerobic da aka gano. Abubuwa daban-daban, ciki har da lahani a cikin aikin fibroblast, matsalolin samuwar collagen, hanyoyin garkuwar jiki na ƙwayoyin halitta, da aikin phagocyte, na iya hana warkar da raunuka a cikin marasa lafiya masu ciwon suga. Nazarce-nazarce da dama sun gano cewa rashin iskar oxygen a fata a matsayin babban abin da ke haifar da yankewar fata da suka shafi DFIs.
A matsayin ɗaya daga cikin zaɓuɓɓukan yanzu don maganin DFIAn ruwaito cewa HBOT yana ƙara yawan warkarwa ga raunukan ƙafafu masu ciwon suga, wanda hakan ke rage buƙatar yanke ƙafafu da kuma hanyoyin tiyata masu rikitarwa. Ba wai kawai yana rage buƙatar hanyoyin da suka shafi albarkatu ba, kamar tiyatar flap da dashen fata, har ma yana gabatar da ƙananan kuɗaɗe da ƙananan illa idan aka kwatanta da zaɓuɓɓukan tiyata. Wani bincike da Chen da abokan aikinsa suka yi ya nuna cewa fiye da zaman HBOT 10 sun haifar da ci gaba da kashi 78.3% a yawan warkar da raunuka a cikin marasa lafiya da ciwon suga.
2. Kamuwa da Cututtukan Nama Mai Taushi
Cututtukan da ke haifar da ƙwayoyin cuta masu laushi (NSTIs) galibi suna da ƙwayoyin cuta masu yawa, galibi suna tasowa ne daga haɗuwar ƙwayoyin cuta masu saurin kamuwa da cuta kuma galibi suna da alaƙa da samar da iskar gas. Duk da cewa NSTIs ba kasafai suke ba, suna da yawan mace-mace saboda saurin ci gaban su. Gano cutar da magani cikin lokaci da dacewa sune mabuɗin cimma sakamako mai kyau, kuma an ba da shawarar HBOT a matsayin hanyar da ta dace don magance NSTIs. Duk da cewa akwai takaddama game da amfani da HBOT a cikin NSTIs saboda rashin nazarin da ake yi,Shaidun da aka bayar sun nuna cewa yana iya kasancewa da alaƙa da ingantaccen ƙimar rayuwa da kiyaye gabobi a cikin marasa lafiya na NSTIWani bincike da aka yi a baya-bayan nan ya nuna raguwar mace-mace a tsakanin marasa lafiyar NSTI da ke karɓar HBOT.
1.3 Kamuwa da Cututtukan da ke Wurin Tiyata
Ana iya rarraba SSIs bisa ga wurin da cutar ta samo asali kuma tana iya tasowa daga cututtuka daban-daban, gami da ƙwayoyin cuta masu kama da aerobic da anaerobic. Duk da ci gaba a matakan kula da kamuwa da cuta, kamar dabarun hana kamuwa da cuta, amfani da maganin rigakafi na rigakafi, da haɓakawa a ayyukan tiyata, SSIs har yanzu matsala ce mai ɗorewa.
Wani muhimmin bita ya binciki ingancin HBOT wajen hana SSIs masu zurfi a tiyatar scoliosis ta jijiyoyi. HBOT kafin tiyata na iya rage yawan SSIs sosai da kuma sauƙaƙe warkar da rauni. Wannan maganin da ba shi da illa yana ƙirƙirar yanayi inda matakan iskar oxygen a cikin kyallen rauni ke ƙaruwa, wanda aka danganta da aikin kashe ƙwayoyin cuta. Bugu da ƙari, yana magance raguwar matakan jini da iskar oxygen waɗanda ke ba da gudummawa ga ci gaban SSIs. Bayan sauran dabarun hana kamuwa da cuta, an ba da shawarar HBOT musamman don tiyatar da aka gurbata kamar hanyoyin hanji.
1.4 Ƙonewa
Konewa raunuka ne da zafi mai tsanani, wutar lantarki, sinadarai, ko radiation ke haifarwa kuma suna iya haifar da yawan rashin lafiya da mace-mace. HBOT yana da amfani wajen magance ƙonewa ta hanyar ƙara yawan iskar oxygen a cikin kyallen da suka lalace. Yayin da nazarin dabbobi da na asibiti ke nuna sakamako iri-iri game daingancin HBOT a cikin maganin ƙonewa, wani bincike da ya shafi marasa lafiya 125 da suka ƙone ya nuna cewa HBOT bai nuna wani tasiri mai mahimmanci akan yawan mace-mace ko adadin tiyata da aka yi ba amma ya rage matsakaicin lokacin warkarwa (kwanaki 19.7 idan aka kwatanta da kwanaki 43.8). Haɗa HBOT tare da cikakken sarrafa ƙonewa zai iya sarrafa sepsis yadda ya kamata a cikin marasa lafiya da suka ƙone, wanda ke haifar da gajerun lokutan warkarwa da rage buƙatun ruwa. Duk da haka, ana buƙatar ƙarin bincike mai zurfi don tabbatar da rawar da HBOT ke takawa wajen sarrafa ƙonewa mai yawa.
1.5 Ciwon Osteomyelitis
Osteomyelitis kamuwa ce ta ƙashi ko ƙashi wanda galibi ƙwayoyin cuta ke haifarwa. Maganin osteomyelitis na iya zama ƙalubale saboda ƙarancin jini ga ƙashi da kuma ƙarancin shigar ƙwayoyin cuta cikin ƙashi. Osteomyelitis na yau da kullun yana da alaƙa da ƙwayoyin cuta masu ci gaba, kumburi mai sauƙi, da kuma samuwar ƙwayoyin ƙashi na necrotic. Osteomyelitis mai ratsa jiki yana nufin cututtukan ƙashi na yau da kullun waɗanda ke ci gaba ko sake faruwa duk da maganin da ya dace.
An nuna cewa HBOT yana inganta yawan iskar oxygen a cikin kyallen ƙashi da suka kamu da cutar. Yawancin bincike da aka gudanar sun nuna cewa HBOT yana inganta sakamakon asibiti ga marasa lafiya da ke fama da cutar osteomyelitis. Da alama yana aiki ta hanyoyi daban-daban, ciki har da haɓaka aikin metabolism, danne ƙwayoyin cuta, haɓaka tasirin maganin rigakafi, rage kumburi, da kuma haɓaka warkarwa.Bayan HBOT, kashi 60% zuwa 85% na marasa lafiya da ke fama da cututtukan osteomyelitis na yau da kullun suna nuna alamun rage kamuwa da cuta.
1.6 Cututtukan Fungal
A duk duniya, mutane sama da miliyan uku suna fama da cututtukan fungal na yau da kullun ko na mamayewa, wanda ke haifar da mutuwar sama da mutane 600,000 a kowace shekara. Sakamakon magani ga cututtukan fungal galibi yana raguwa saboda dalilai kamar canjin yanayin garkuwar jiki, cututtuka na asali, da halayen ƙwayoyin cuta. HBOT yana zama zaɓi mai kyau na magani a cikin cututtukan fungal masu tsanani saboda aminci da yanayinsa mara yaduwa. Bincike ya nuna cewa HBOT na iya yin tasiri ga cututtukan fungal kamar Aspergillus da Mycobacterium tarin fuka.
HBOT yana haɓaka tasirin maganin fungal ta hanyar hana samuwar Aspergillus na biofilm, tare da ƙaruwar inganci da aka lura a cikin nau'ikan da ba su da kwayoyin halittar superoxide dismutase (SOD). Yanayin hypoxic a lokacin kamuwa da cututtukan fungal yana haifar da ƙalubale ga isar da magungunan fungal, wanda hakan ya sa ƙaruwar iskar oxygen daga HBOT ya zama maganin da zai iya zama mai amfani, kodayake ana buƙatar ƙarin bincike.
Abubuwan da ke hana ƙwayoyin cuta na HBOT
Yanayin da HBOT ya ƙirƙira yana fara canje-canje a fannin jiki da na sinadarai waɗanda ke ƙarfafa halayen ƙwayoyin cuta, wanda hakan ke sa shi ya zama magani mai tasiri ga kamuwa da cuta. HBOT yana nuna tasirin gaske akan ƙwayoyin cuta masu kama da na iskar oxygen da kuma ƙwayoyin cuta masu kama da anaerobic ta hanyar hanyoyin kamar aikin kashe ƙwayoyin cuta kai tsaye, haɓaka martanin garkuwar jiki, da tasirin haɗin gwiwa tare da takamaiman magungunan kashe ƙwayoyin cuta.
2.1 Tasirin Kwayar cuta Kai Tsaye na HBOT
Tasirin kai tsaye na HBOT yana da alaƙa da samar da nau'ikan oxygen masu amsawa (ROS), waɗanda suka haɗa da anions na superoxide, hydrogen peroxide, radicals na hydroxyl, da ions na hydroxyl - duk waɗanda ke tasowa yayin metabolism na ƙwayoyin halitta.
Hulɗar da ke tsakanin O₂ da sassan tantanin halitta yana da mahimmanci wajen fahimtar yadda ROS ke samuwa a cikin tantanin halitta. A ƙarƙashin wasu yanayi da ake kira damuwa ta oxidative, daidaito tsakanin samuwar ROS da lalacewarsa yana katsewa, wanda ke haifar da ƙaruwar matakan ROS a cikin tantanin halitta. Ana samar da superoxide (O₂⁻) ta hanyar superoxide dismutase, wanda daga baya ya canza O₂⁻ zuwa hydrogen peroxide (H₂O₂). Wannan juyi yana ƙara ƙaruwa ta hanyar amsawar Fenton, wanda ke oxidize Fe²⁺ don samar da radicals hydroxyl (·OH) da Fe³⁺, don haka yana fara jerin redox masu illa na samuwar ROS da lalacewar tantanin halitta.
Tasirin guba na ROS yana kai hari ga muhimman sassan tantanin halitta kamar DNA, RNA, sunadarai, da lipids. Abin lura shi ne, DNA babban abin da ke haifar da gubar da H₂O₂ ke haifarwa, domin yana wargaza tsarin deoxyribose kuma yana lalata abubuwan da ke cikin tushe. Lalacewar jiki da ROS ke haifarwa ta kai ga tsarin helix na DNA, wanda hakan ke iya faruwa sakamakon lipid peroxidation da ROS ke haifarwa. Wannan yana nuna mummunan sakamakon karuwar matakan ROS a cikin tsarin halittu.
Ayyukan Magungunan Ƙwayoyin cuta na ROS
ROS tana taka muhimmiyar rawa wajen hana ci gaban ƙwayoyin cuta, kamar yadda aka nuna ta hanyar samar da ROS da HBOT ta haifar. Tasirin guba na ROS kai tsaye yana kai hari ga abubuwan da ke cikin ƙwayoyin halitta kamar DNA, sunadarai, da lipids. Yawan yawan iskar oxygen mai aiki na iya lalata lipids kai tsaye, wanda ke haifar da lipid peroxidation. Wannan tsari yana lalata amincin membranes na ƙwayoyin halitta, kuma sakamakon haka, aikin masu karɓa da furotin da ke da alaƙa da membrane.
Bugu da ƙari, sunadaran, waɗanda suma muhimman abubuwan da ROS ke nufi ne ga ƙwayoyin halitta, suna fuskantar takamaiman gyare-gyare na oxidative a wasu ragowar amino acid kamar cysteine, methionine, tyrosine, phenylalanine, da tryptophan. Misali, an nuna cewa HBOT yana haifar da canje-canje na oxidative a cikin furotin da yawa a cikin E. coli, gami da ma'aunin elongation G da DnaK, wanda hakan ke shafar ayyukansu na ƙwayoyin halitta.
Inganta garkuwar jiki ta hanyar HBOT
Halayen hana kumburi na HBOTAn rubuta su, wanda hakan ya tabbatar da cewa yana da mahimmanci wajen rage lalacewar nama da kuma rage ci gaban kamuwa da cuta. HBOT yana da tasiri sosai ga bayyanar cytokines da sauran masu daidaita kumburi, wanda ke tasiri ga martanin garkuwar jiki. Tsarin gwaji daban-daban sun lura da canje-canje daban-daban a cikin bayyanar kwayoyin halitta da samar da furotin bayan HBOT, wanda ko dai yana haɓaka ko rage abubuwan ci gaba da cytokines.
A lokacin aikin HBOT, ƙaruwar matakan O₂ yana haifar da martani iri-iri na ƙwayoyin halitta, kamar hana sakin masu shiga tsakani masu hana kumburi da haɓaka lymphocytes da neutrophil apoptosis. Gabaɗaya, waɗannan ayyukan suna haɓaka hanyoyin hana ƙwayoyin cuta na tsarin garkuwar jiki, ta haka ne ke sauƙaƙe warkar da cututtuka.
Bugu da ƙari, bincike ya nuna cewa ƙaruwar matakan O₂ a lokacin HBOT na iya rage bayyanar cytokines masu hana kumburi, gami da interferon-gamma (IFN-γ), interleukin-1 (IL-1), da interleukin-6 (IL-6). Waɗannan canje-canjen sun haɗa da rage rabon ƙwayoyin T na CD4: CD8 da daidaita sauran masu karɓa mai narkewa, a ƙarshe haɓaka matakan interleukin-10 (IL-10), wanda yake da mahimmanci don magance kumburi da haɓaka warkarwa.
Ayyukan ƙwayoyin cuta na HBOT suna da alaƙa da hadaddun hanyoyin halittu. An ruwaito cewa superoxide da hauhawar matsin lamba suna haɓaka aikin ƙwayoyin cuta da HBOT ke haifarwa da kuma apoptosis na neutrophil. Bayan HBOT, ƙaruwar matakan iskar oxygen mai yawa yana haɓaka ƙarfin kashe ƙwayoyin cuta na neutrophils, wani muhimmin sashi na amsawar garkuwar jiki. Bugu da ƙari, HBOT yana danne mannewar neutrophil, wanda ke shiga tsakani ta hanyar hulɗar β-integrins akan neutrophils tare da ƙwayoyin mannewar intercellular (ICAM) akan ƙwayoyin endothelial. HBOT yana hana aikin neutrophil β-2 integrin (Mac-1, CD11b/CD18) ta hanyar tsari mai nitric oxide (NO), yana ba da gudummawa ga ƙaura na neutrophils zuwa wurin da kamuwa da cuta ta faru.
Daidaita tsarin cytoskeleton yana da mahimmanci ga neutrophils don haɓaka ƙwayoyin cuta yadda ya kamata. An nuna cewa S-nitrosylation na actin yana ƙarfafa polymerization na actin, wanda zai iya sauƙaƙe aikin phagocytic na neutrophils bayan magani na HBOT. Bugu da ƙari, HBOT yana haɓaka apoptosis a cikin layukan ƙwayoyin T na ɗan adam ta hanyar hanyoyin mitochondrial, tare da rahoton mutuwar lymphocyte mai sauri bayan HBOT. Toshe caspase-9—ba tare da yin tasiri ga caspase-8 ba—ya nuna tasirin immunomodulatory na HBOT.
Tasirin Hadin Gwiwa na HBOT tare da Magungunan Antimicrobial
A aikace-aikacen asibiti, ana yawan amfani da HBOT tare da maganin rigakafi don yaƙar cututtuka yadda ya kamata. Yanayin da aka samu a lokacin HBOT na iya yin tasiri ga ingancin wasu magungunan rigakafi. Bincike ya nuna cewa takamaiman magungunan kashe ƙwayoyin cuta, kamar β-lactams, fluoroquinolones, da aminoglycosides, ba wai kawai suna aiki ta hanyar hanyoyin da ke cikin jiki ba, har ma suna dogara ne akan tsarin metabolism na ƙwayoyin cuta na aerobic. Saboda haka, kasancewar iskar oxygen da halayen metabolism na ƙwayoyin cuta suna da mahimmanci lokacin kimanta tasirin maganin rigakafi.
Shaida mai mahimmanci ta nuna cewa ƙarancin iskar oxygen na iya ƙara juriyar Pseudomonas aeruginosa ga piperacillin/tazobactam kuma cewa yanayin iskar oxygen mara kyau shima yana taimakawa wajen ƙara juriyar Enterobacter cloacae ga azithromycin. Akasin haka, wasu yanayi na hypoxic na iya ƙara yawan jin daɗin ƙwayoyin cuta ga maganin rigakafi na tetracycline. HBOT yana aiki azaman hanyar magani mai inganci ta hanyar haifar da metabolism na aerobic da sake kunna kyallen da suka kamu da hypoxic, daga baya yana ƙara yawan jin daɗin ƙwayoyin cuta ga maganin rigakafi.
A cikin binciken da aka yi kafin a fara aiki, haɗin HBOT—wanda aka yi sau biyu a rana na tsawon awanni 8 a 280 kPa—tare da tobramycin (20 mg/kg/rana) ya rage yawan ƙwayoyin cuta a cikin Staphylococcus aureus infectious endocarditis. Wannan yana nuna yuwuwar HBOT a matsayin magani na taimako. Ƙarin bincike sun nuna cewa a ƙarƙashin 37°C da matsin lamba ATA guda 3 na tsawon awanni 5, HBOT ya inganta tasirin imipenem akan Pseudomonas aeruginosa da ke kamuwa da macrophage. Bugu da ƙari, an gano cewa haɗin HBOT tare da cephazolin ya fi tasiri wajen magance Staphylococcus aureus osteomyelitis a cikin samfuran dabbobi idan aka kwatanta da cephazolin kaɗai.
HBOT kuma yana ƙara yawan aikin kashe ƙwayoyin cuta na ciprofloxacin akan biofilms na Pseudomonas aeruginosa, musamman bayan mintuna 90 na fallasa. Wannan haɓakawa an danganta shi da samuwar nau'in iskar oxygen mai amsawa (ROS) kuma yana nuna ƙaruwar jin daɗi a cikin maye gurbi masu lahani na peroxidase.
A cikin samfuran pleuritis da Staphylococcus aureus (MRSA) mai juriya ga methicillin ke haifarwa, tasirin haɗin gwiwa na vancomycin, teicoplanin, da linezolid tare da HBOT ya nuna ƙaruwar inganci sosai akan MRSA. Metronidazole, maganin rigakafi wanda ake amfani da shi sosai wajen magance cututtukan anaerobic da polymicrobial masu tsanani kamar cututtukan ƙafa na masu ciwon suga (DFIs) da cututtukan wurin tiyata (SSIs), ya nuna ingantaccen maganin rigakafi a ƙarƙashin yanayin anaerobic. Nazarin da za a yi nan gaba ya zama dole don bincika tasirin antibacterial na HBOT tare da metronidazole a cikin yanayin in vivo da in vitro.
Ingancin Magungunan HBOT akan Kwayoyin cuta Masu Juriya
Tare da ci gaban da yaduwar nau'ikan da ke jure wa magani, magungunan rigakafi na gargajiya galibi suna rasa ƙarfinsu akan lokaci. Bugu da ƙari, HBOT na iya zama mahimmanci wajen magancewa da hana kamuwa da cuta da ƙwayoyin cuta masu jure wa magunguna da yawa ke haifarwa, wanda ke aiki a matsayin muhimmiyar dabarar lokacin da magungunan rigakafi suka gaza. Nazari da yawa sun ba da rahoton tasirin kashe ƙwayoyin cuta na HBOT akan ƙwayoyin cuta masu jure wa magani. Misali, zaman HBOT na minti 90 a 2 ATM ya rage girman MRSA sosai. Bugu da ƙari, a cikin samfuran rabo, HBOT ya haɓaka tasirin kashe ƙwayoyin cuta na ƙwayoyin cuta daban-daban akan cututtukan MRSA. Rahotanni sun tabbatar da cewa HBOT yana da tasiri wajen magance osteomyelitis da cutar Klebsiella pneumoniae da ke samar da OXA-48 ke haifarwa ba tare da buƙatar wani maganin rigakafi ba.
A taƙaice, maganin iskar oxygen mai ƙarfi yana wakiltar wata hanya mai fuskoki da dama ta magance kamuwa da cuta, yana ƙara ƙarfin garkuwar jiki yayin da kuma yana ƙara ingancin magungunan kashe ƙwayoyin cuta da ake da su. Tare da cikakken bincike da haɓakawa, yana da yuwuwar rage tasirin juriyar maganin rigakafi, yana ba da bege a yaƙin da ake yi da kamuwa da ƙwayoyin cuta.
Lokacin Saƙo: Fabrairu-28-2025