Shanyewar jiki, wani yanayi mai muni da ke tattare da raguwar samar da jini kwatsam ga nama a cikin kwakwalwa saboda ciwon jini ko ciwon ischemic pathology, shi ne na biyu da ke haifar da mutuwa a duk duniya kuma na uku kan haddasa nakasa. Manyan nau'ikan nau'ikan bugun jini guda biyu sune bugun jini na ischemic (lissafin kashi 68%) da bugun jini (32%). Duk da bambance-bambancen ilimin pathophysiology a cikin matakan farko, duka biyu suna haifar da raguwa a cikin samar da jini da kuma ischemia na gaba na cerebral a lokacin matakan subacute da na yau da kullun.
Ischemic bugun jini
Ischemic bugun jini (AIS) yana da alamar rufewar jijiya kwatsam, wanda ke haifar da lalacewar ischemic ga yankin da abin ya shafa. A cikin matsanancin lokaci, wannan mahalli na farko na hypoxic yana haifar da ɓarna na excitotoxicity, damuwa na oxidative, da kunna microglia, wanda ke haifar da mutuwar neuronal da yawa. A lokacin lokacin subacute, sakin cytokines, chemokines, da matrix metalloproteinases (MMPs) na iya ba da gudummawa ga neuroinflammation. Musamman ma, matakan da aka ɗaukaka na MMPs suna ƙara haɓakar shinge na kwakwalwa na jini (BBB), yana ba da izinin ƙaura na leukocyte zuwa yankin da aka yi wa rauni, yana kara tsananta ayyukan kumburi.
Magani na Yanzu don Ciwon Ischemic Stroke
Babban mahimmancin jiyya na AIS sun haɗa da thrombolysis da thrombectomy. Thrombolysis na ciki zai iya amfanar marasa lafiya a cikin sa'o'i 4.5, inda jiyya na farko ke fassara zuwa mafi girma. Idan aka kwatanta da thrombolysis, thrombectomy na inji yana da taga magani mai faɗi. Bugu da ƙari, marasa amfani da magunguna, hanyoyin kwantar da hankali kamar suoxygen far, acupuncture, da kuma motsa jiki na lantarki suna samun karfin jiki a matsayin magungunan haɗin gwiwa zuwa hanyoyin al'ada.
Tushen Farfadowar Magungunan Oxygen Hyperbaric (HBOT)
A matsa lamba na teku (1 ATA = 101.3 kPa), iskar da muke shaka ta ƙunshi kusan 21% oxygen. A karkashin yanayin ilimin lissafi, adadin iskar oxygen a cikin jini yana da kadan, kusan 0.29 ml (0.3%) a cikin 100 ml na jini. A ƙarƙashin yanayin hyperbaric, shakar 100% oxygen yana ƙara yawan narkar da matakan oxygen a cikin plasma sosai-har zuwa 3.26% a 1.5 ATA da 5.6% a 2.5 ATA. Saboda haka, HBOT yana nufin haɓaka wannan ɓangaren narkar da iskar oxygen, yadda ya kamataƙara yawan ƙwayar iskar oxygen a cikin yankunan ischemic. A mafi girman matsi, iskar oxygen yana yaɗuwa cikin hanzari zuwa cikin kyallen jikin jiki, yana kaiwa nesa mai tsayi idan aka kwatanta da yanayin yanayi na yau da kullun.
Har zuwa yau, HBOT ya ga aikace-aikace da yawa don duka ischemic da bugun jini. Nazarin ya nuna cewa HBOT yana ba da tasirin neuroprotective ta hanyar hadaddun kwayoyin halitta, biochemical, da hanyoyin hemodynamic, gami da:
1. Ƙara yawan iskar oxygen na jijiya, inganta isar da iskar oxygen zuwa ƙwayar kwakwalwa.
2. Tabbatar da BBB, rage kumburin kwakwalwa.
3. Inganta kwakwalwamicrocirculation, inganta kwakwalwa metabolism da kuma samar da makamashi yayin da kula da salon salula ion homeostasis.
4. Tsarin jini na kwakwalwa don rage karfin intracranial da rage kumburin kwakwalwa.
5. Attenuation na neuroinflammation post-stroke.
6. Ragewar apoptosis da necrosisbin bugun jini.
7. Rage damuwa na oxidative da kuma hana raunin reperfusion, mai mahimmanci a cikin ilimin cututtuka na bugun jini.
8. Bincike ya nuna cewa HBOT na iya rage vasospasm bayan zubar jini na subarachnoid aneurysmal (SAH).
9. Shaida kuma tana goyan bayan fa'idar HBOT don haɓaka neurogenesis da angiogenesis.
Kammalawa
Hyperbaric oxygen far yana ba da kyakkyawar hanya don maganin bugun jini. Yayin da muke ci gaba da bayyana abubuwan da ke tattare da murmurewa bugun jini, ƙarin bincike zai zama mahimmanci don daidaita fahimtarmu game da lokaci, sashi, da hanyoyin HBOT.
A taƙaice, yayin da muke bincika fa'idodin magungunan hyperbaric oxygen don bugun jini, ya bayyana a fili cewa yin amfani da wannan magani yana da yuwuwar sauya yadda muke gudanar da shanyewar ischemic, yana ba da bege ga waɗanda wannan yanayin ke canza rayuwa ya shafa.
Idan kuna sha'awar bincika hyperbaric oxygen far a matsayin yuwuwar jiyya don dawo da bugun jini, muna gayyatarku ku ziyarci gidan yanar gizon mu don ƙarin koyo game da ɗakunan oxygen ɗin mu na gaba. Tare da nau'ikan nau'ikan nau'ikan da aka tsara don amfani da gida da ƙwararru, MACY-PAN yana ba da mafita waɗanda ke ba da inganci mai inganci, maganin iskar oxygen da aka yi niyya don tallafawa lafiyar ku da tafiyar dawowa.
Gano samfuran mu da yadda za su iya haɓaka jin daɗin ku awww.hbotmacypan.com.
Lokacin aikawa: Fabrairu-18-2025